If sufficient nutritional change is not sufficient to reach the appropriate target values (table), additional (combination) drug therapy is required.
If a vascular event has already occurred, the drug therapy must be initiated immediately and maintained for a period of time (under regular control).
arget values of lipid therapy
Parameter
|
Prevention
|
Therapy
|
CH
|
< 200
|
< 160
|
HDL
|
> 50
|
> 50
|
LDL²
|
< 130
|
< 100
|
CH/HDL
|
< 5
|
< 3
|
TG
|
< 200
|
< 200
|
Lp(a)
|
< 30
|
< 30
|
non-HDL-CH*²
|
< 160
|
< 130
|
non HDL-Lp**²
|
< 190
|
< 160
|
CH = Cholesterol; HDL = high-density Lipoprotein; LDL = low-density Lipoprotein; TG= Triglyceride; Lp(a) = Lipoprotein(a); all limits (except CH/HDL) in mg/dl; CH: 1 mmol/l = 38.7 mg/dl; TG: 1 mmol/l = 88.6 mg/dl; * non-HDL-Cholesterol (Cholesterol – HDL cholesterol) is easier and cheaper
to calculate than LDL cholesterol for risk assessment (assessment of a future vascular event or death); ** the inclusion of Lp (a) for which a value of max. 30 mg / dl is the best way to take into account the risk of increased Lp (a) for the therapy decision; ¹optimal: < 150; ²30 Rule (Difference between primary and secondary prevention)
|